What is CBD?

What is CBD?

Cannabidiol is one of the 113 cannabinoids found in the cannabis plant. It constitutes up to 40% of the plants extracts. CBD pain relief is one of the more frequent health benefits associated with this compound.

Other common uses of CBD include the treatment of anxiety and sleeping difficulties. The Food and Drug Administration (FDA) approved the use of Epidiolex in the United States in 2018. This cannabidiol medication is used for the treatment of epilepsy. Of course, there are various other reputable FDA approved CBD brands and products introduced.

The chemical compounds found in the cannabis plants are called cannabinoids. These compounds are responsible for the therapeutic effects of the cannabis plant. The most common cannabinoids are:

  • THC (tetrahydrocannabinol): This compound is the chief psychoactive cannabinoid in the cannabis plant and is responsible for the feeling of euphoria.
  • CBD: CBD is responsible for the therapeutic effects and is non-psychoactive. Physical benefits of CBD include pain relief, reduced nausea, prevention of seizures and relief from anxiety and migraines. In addition, you can use CBD for chronic back pain as well as arthritis symptoms.
  • CBN (cannabinol): Cannabinol is responsible for the relief of neurological conditions and symptoms. CBN is mildly psychoactive and is a by-product of THC. Heating and exposing THC to light breaks down the compound and leaves behind CBN.
  • CBG (cannabigerol): This cannabinoid is for the relief of symptoms related to anxiety disorders such as obsessive compulsive disorder (OCD) and post traumatic stress disorder (PTSD).
  • THCA (tetrahydrocannabinolic acid): This cannabinoid is similar to THC but differs in that it does not produce any psychotic effects.

Terpenes Give Cannabis Its Unique Aroma

Terpenes are naturally occurring compounds in the cannabis flower. They are known for their role in creating the smell of the plant but have gained momentum and popularity with regard to their therapeutic benefits, much like CBD.

Adding terpenes to CBD allows for greater benefits as these compounds work together in what is known as the “entourage effect.” The entourage effect is a proposed mechanism that suggests that the compounds of the cannabis plant function synergistically to bring about enhanced therapeutic effects. There are several terpenes identified, examples include:

  • Myrcene: Myrcene is a significant component of the essential oils of cannabis, lemongrass, hops and bay plants, to name a few. This is the most common terpene and is rarely used directly as it is unstable in air. This terpene is thought to be useful for relieving anxiety symptoms and insomnia.
  • Linalool: There are over 200 plants known to contain linalool. This terpene is used in 60% to 80% of hygiene products such as soaps and shampoos. Linalool is believed to improve mood and promote relaxation. It can therefore be useful for conditions such as anxiety and depression.
  • Bisabolol: This terpene is used in various fragrances and has a weak floral aroma. For many years, bisabolol has been used in cosmetics to create fragrance and for its skin healing properties. With notes of chamomile, bisabolol is said to reduce inflammation and irritation, making it useful for skin conditions such as acne. This terpene is also known for its pain relieving and antimicrobial properties.
  • Terpinolene: The smells created by this terpene are similar to that of apples and cumin. Terpinolene may have antibacterial and antifungal properties as an essential oil. Research suggests that this terpene may also be useful in warding off insects like mosquitoes. When combined with cannabis, this compound may be useful for sedation.

Limonene: As the name suggests this terpene is responsible for the smell of citrus fruit, particularly lemons. In nature, this terpene occurs in the fragrance of citrus fruit. It is also used as a flavouring agent in the manufacturing of food. Limonene is said to reduce stress levels and improve mood. Thus, this terpene can be effectively used as part of an anxiety treatment plan.

CBD Capsules Treat Muscle and Joint Pain

CBD Capsules

Joint and muscle pain are conditions that can negatively affect a person's quality of life. It can make it difficult to perform tasks and activities properly in day to day life. Living with these types of general body pain can become a nuisance as well as possibly pose greater health risks later on in life.

Fortunately, CBD tablets / capsules in the UK and EU can help alleviate your pain. These CBD capsules contain CBD oil, a medication that has been very successful with treating multiple conditions including anxiety, stress and insomnia. CBD is extracted from the hemp plant which makes this medication a healthy and safe alternative, particularly in comparison to strong analgesics.

Many people choose CBD Brothers capsules due to their ease of use. Physically, CBD capsules look exactly the same as any other capsule on the market. This makes this treatment easy and convenient for users. Simply ingest the capsules with some water and wait as your pain is alleviated.

CBD For Pain: Mechanism of Action

Cannabidiol is a pleiotropic chemical compound, meaning it has multiple therapeutic effects through several molecular pathways. Research has identified at least 65 molecular pathways targeted for CBD pain relief. Some of the therapeutic effects of CBD are brought about through interaction with:

Vanilloid Receptors: Vanilloids are compounds that possess a vanillyl group. The most common vanilloid is capsaicin and these compounds bind to receptors which act as ion channels. CBD binds to TRPV1 receptors (Transient receptor potential vanilloid type 1) which are responsible for the mediation of the certain therapeutic effects. These effects specifically include pain perception, body temperature and inflammation.

Serotonin Receptors: CBD binds to the serotonin receptor, 5-HT1A (hydoxytryptamine), which mediates anti-anxiety effects at high concentrations. This receptor is involved in several neurological and biological processes such as sleep, appetite, nausea, vomiting, pain and anxiety.

Hydroxytrypamine is a member of the 5-HT family of receptors and these are activated by the neurotransmitter, serotonin. These receptors are found in the central nervous system and the peripheral nervous system. The 5-HT receptors facilitate chemical messages to produce an excitatory or inhibitory effect, based on the context of the message.

Cannabidiolic acid (CBDA) is the raw unheated version of CBD and has a greater affinity for serotonin receptors than CBD. Studies also indicate that CBDA has great anti-emetic properties, even more so than cannabidiol.

GPR55 - Orphan Receptors: The GPR55 receptor is an atypical cannabinoid receptor which can be activated by certain endogenous cannaibinoids. CBD acts as an antagonist which deactivates or blocks the GRP55 receptors. These receptors are involved in the modulation of various physiological processes such as blood pressure. They are most prevalently expressed in the cerebellum part of the brain.

GRP55 is also involved in the promotion of osteoclast cell function. The osteoclast disassembles protein and minerals at a molecular level through as process known as bone resorption. This process also regulates the level of calcium in the blood. Overactive signalling of the GRP55 receptors is associated with the bone disease, osteoporosis.

Activation of the GRP55 receptors promotes cancer cell proliferation, as suggested by the researchers of the Chinese Academy of Sciences. CBD is an antagonist of GRP55 and by blocking GRP55 signalling, cancer cell proliferation and bone reabsorption may both be decreased - according to the scientist Ruth Ross of the University of Aberdeen.

CBD as an Allosteric Modulator

Cannabidiol can function as an allosteric receptor modulator. This means it can change the shape of receptors which will dictate the manner in which the receptor can transmit signals, either by enhancing or inhibiting it.

CBD reduces anxiety by altering the shape of the GABA-A receptor in a manner which amplifies the calming effects of GABA (gamma aminobutyric acid), the chief inhibitory neurotransmitter of the CNS. There is extensive research to the type of allosteric modulator that CBD may be.

Australian scientists believe that CBD is a positive allosteric modulator of the GABA-A receptor. This suggests that CBD interacts with the receptor in a way that enhances the binding affinity of the receptor for GABA. Canadian scientists suggest that CBD acts as a negative allosteric modulator of the CBD1 receptor. Negative allosteric modulators inhibit or decrease the activity of the GABA-A receptor protein.

Types of CBD Oil for Pain

Deciding on the best CBD oil for pain is a complicated issue, especially with the numerous products available on the market. There are considerations, other than CBD and THC composition, to take note of. There are three types of categories, based on the cannabis plant type, which the medication can fall into:

  • Sativa
  • Indica
  • Hybrid (a mixture of sativa and indica)
  • Inidica: Cannibis indica is a short plant whose growth is typically widespread. They can be seen as bushy greenery and generally grow faster than the sativa plant type. They have more buds in each plant that their counterparts.

Indigenous to Pakistan, India, Turkey and Afghanistan, these plants are adaptive to areas which are dry and exposed to harsh conditions - much like the turbulent conditions of the Hindu Kush Mountains (a popular location for Cannibis indica growth).

Indica strains (which are a subcategory for indica plants) have more CBD than THC and are known for the relaxing and calming sensations it produces. These strains are used for treating anxiety, reducing nausea and increasing appetite. Indica is also a suitable type of CBD for chronic back pain.

  • Sativa: Cannibis sativa are identified by their finger-like leaves and grow taller and thinner than the indica plant type. These plants can grow up to 12 feet high and mature at a slower rate.

They have lower levels of CBD than THC and typically grow in hot climates. They are native to Africa, Central America and Southeast Asia. Sativa plants are known for producing stimulating and energising effects. They are commonly used to treat fatigue, depression, anxiety and stress.

  • Hybrids: Hybrids are generally grown in greenhouses and farms and are a combination of the indica and sativa plant types. Their appearance depends on how they are cultivated and the parent plants involved in this cultivation. Their effects are also dependent on the parent plants.

Aside from the category of plant types, this can be further divided into strains. A strain is a designated group which arises from the plant type.

Popular Indica Strains

  • Purple kush: For chronic pain, insomnia and muscle tension
  • Bubba kush: For insomnia, acute pain, increasing appetite, anxiety disorders and nausea
  • Granddaddy purple: For low appetite, sleep difficulties and restless leg syndrome
  • LA confidential: For stress, pain and inflammation
  • Afghan kush: For Acute pain and sleep disturbances
  • Northern lights: For Insomnia, increasing appetite, mood disorders, and pain

Popular Sativa Strains include the following:

  • Maui waui: For depression and fatigue
  • Super silver haze: For stress, anxiety and increasing energy levels
  • Supernatural: For headaches, mood disorders and glaucoma

Popular Hybrid Strains include the following:

  • White widow: For stress, mental difficulties and anxiety disorders
  • Pineapple express: For acute pain and anxiety disorders
  • Golden goat: For depression, anxiety and increasing energy levels

Why Use CBD Oil for Pain?

The pain relief of CBD is considered by many to be equivalent to that of prescription pain relievers. Analgesic prescription medications are chemically synthesised to provide pain relief. The most commonly includes opioids and NSAIDs (non-steroidal anti-inflammatory drugs). These medications require a prescription and cannot be purchased over-the-counter.

Cannabidiol has analgesic properties for several conditions, including chronic conditions such as multiple sclerosis. Using CBD for chronic back pain is also relatively common, especially amongst seniors. An in depth survey conducted by the Brightfield Research Group on CBD was carried out. It reported that 60% of its survey participants said that, to some extent, CBD was more effective than their current or previous pharmaceutical approaches.

Fewer Side Effects than Prescription Medication

It is widely known that the use of prescription medication comes with the possibility of some serious adverse effects. The side effects of opioids and NSAIDs can be complicated and can range from mild to severe.

When using CBD oil for pain, the adverse effects associated with CBD are often rare or minor. Even in the event of mild side effects, these often tend to be short-lived. CBD for pain, and other ailments, would be considered a safer option in terms of the negative effects resulting from use.

CBD for Pain Is Less Addictive

Opioids and NSAIDs carry a high potential for being misused. In fact, this is a common concern for all prescription medication. Of all the addictive prescription medications, opiates are the most frequently abused. It has been reported than almost sixty people die from opioid abuse every day in the United States alone.

CBD alone contains less than 0.3% THC so it does not create any feelings of euphoria. The safety profile with regards to addiction is much better with CBD than prescription analgesics. The best CBD oil for pain is beneficial for several conditions without causing any harm to the body.

You Can Choose the Delivery System Most Appropriate For You

CBD, for pain, anxiety and other disorders, can be used in a variety of methods and you can choose which delivery system is the most appropriate for you. If its discretion you require, CBD may be consumed in the form of edibles, such as gummie bears, or in capsule/ tablet form. If you require fast relief, administration of CBD is best through the inhalation of vaporised CBD oils.

Compounds which are inhaled are absorbed directly into the bloodstream, via the lungs. CBD oil for pain does not even have to be physically consumed. There are CBD products, such as lotions and creams, which are also available for pain relief. These are commonly used to treat skin conditions like acne.

The list of CBD products is extensive and increasingly growing based on the popularity of this therapeutic compound. You can buy the best CBD oil for pain from a reputable online pharmacy which retails only high-quality products.

Finding Your Ideal CBD Dosage for Pain

CBD Dosage for Pain

When determining how much CBD oil for pain relief is best for you, it is advisable to try out the medication at different dosages. This can be done until the desired effects are obtained. Each effect differs from person to person and the dosage is dependent on several factors including the following:

  • Body weight: The advised dose of CBD is 6mg for every 10 pounds of body weight. This is the typical dose but can be adjusted depending on the severity of the condition.
  • Body chemistry: A person's body chemistry is unique to them and this will determine how CBD will act in their body. The chemistry of one's body dictates the way the body will process the active ingredient.

You should take note of the effects of CBD following administration and adjust the dosages accordingly until you reach the most ideal dose of CBD to relieve your ailments.

  • CBD concentration: The concentration of CBD in the product you are using plays an important role in determining the most appropriate dosage for you. You should calculate the amount of CBD you will consume based on the strength of CBD oil in the product.

The initial recommended CBD dosage for pain should always be the lowest possible dose. Using too much CBD or overdosing on the compound is rare. Clinical studies have shown that prescribed CBD dosages of up to 1200mg can be used daily, in the long term, without any adverse effects experienced.

The duration of CBD effects is a balance of the ingestion and elimination of the medication into and out of the body, respectively. Some methods allow for the CBD to be quickly absorbed whilst others offer a slower and more contained effect.

For immediate relief, in the short-term, inhalation of vaporised CBD, using vape pens may be best. For CBD levels which are maintained steadily throughout the day, the oral route would be most effective. Examples of the appropriate CBD dosage for pain, and other conditions, are:

  • Arthritis pain: oral supplements taken 1 to 3 times a day and a topical as required
  • Anxiety: oral supplements taken 1 to 3 times a day and a vape pen as required
  • Menstrual cramps: vaginal suppositories as needed
  • Insomnia: Oral supplements taken prior to retiring to bed. Low dosages of CBD are known to increase energy levels but higher doses will assist with sleep difficulties.

Purchase CBD Capsules Online Today

You no longer have to search the internet to find a trustworthy CBD dispensary near you. Now accredited online CBD dispensaries provide customers in the UK and EU with high quality CBD products all sold at affordable prices.

Online CBD dispensaries offer each customer delivery of their CBD capsules. Customers can receive their delivery within 2 to 3 working days if in the UK and within 5 to 7 working days if in the EU. This allows more people to have access to effective and natural medication that will alleviate their pain and leave them feeling healthier and stronger than before.

These dispensaries provide an easy to use online based service. Information regarding each products contents, usage and benefits can easily be found on the designated web page, all information is laid out in an informative and easy to read manner making the online experience of purchasing CBD even easier than before.

CBD Capsules from Our Accredited Online Dispensary

Our accredited online CBD dispensary provides residents of the UK and EU with affordable high quality CBD products that range from oil, balms, isolates, E liquids to capsules. All medication is affordably priced and with the use of our delivery system we ensure that you always have access to the pain relief you want.

Maxwell Wilson

Author: Maxwell Wilson

Max's love of words and language sprouted from his early years when his grandmother began teaching him the English and Latin of every flower shrub and herb imaginable. Slowly instilling the belief that "mother nature provides all, if only we know how to look for it".

Fueled with this knowledge and desire to learn more Max devoted himself to researching holistic lifestyles and the benefits of alternative medicines. Max's vast content portfolio reflects this and his areas of expertise include, modern day farming techniques and alternative medicines.

Marion Smith – Feb 19, 2021
Dear Max, I wanted to write and tell you how much of an impression your blog made with me. The marvels of CBD are new to me and informative may in which you write has opened my mind to the possibilities and healing benefits of CBD. Marion Smith

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